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Activation of IP(3) receptors requires an endogenous 1-8-14 calmodulin-binding motif
Binding of IP(3) (inositol 1,4,5-trisphosphate) to the IP(3)-binding core (residues 224–604) of IP(3)Rs (IP(3) receptors) initiates opening of these ubiquitous intracellular Ca(2+) channels. The mechanisms are unresolved, but require conformational changes to pass through the suppressor domain (resi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3685217/ https://ncbi.nlm.nih.gov/pubmed/23009366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121034 |
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