AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

AS160 (Akt substrate of 160 kDa) is a Rab GTPase-activating protein implicated in insulin control of GLUT4 (glucose transporter 4) trafficking. In humans, a truncation mutation (R363X) in one allele of AS160 decreased the expression of the protein and caused severe postprandial hyperinsulinaemia dur...

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Autors principals: Wang, Hong Yu, Ducommun, Serge, Quan, Chao, Xie, Bingxian, Li, Min, Wasserman, David H., Sakamoto, Kei, Mackintosh, Carol, Chen, Shuai
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685216/
https://ncbi.nlm.nih.gov/pubmed/23078342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120702
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