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AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues
AS160 (Akt substrate of 160 kDa) is a Rab GTPase-activating protein implicated in insulin control of GLUT4 (glucose transporter 4) trafficking. In humans, a truncation mutation (R363X) in one allele of AS160 decreased the expression of the protein and caused severe postprandial hyperinsulinaemia dur...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Portland Press Ltd.
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3685216/ https://ncbi.nlm.nih.gov/pubmed/23078342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120702 |
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