PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis

In RAW 264.7 cells [1], PKC-ε regulates FcγR-mediated phagocytosis. BMDM behave similarly; PKC-ε concentrates at phagosomes and internalization are reduced in PKC-ε(−/−) cells. Two questions were asked: what is the role of PKC-ε? and what domains are necessary for PKC-ε concentration? Function was s...

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Main Authors: Wood, Tiffany R., Chow, Rachel Y., Hanes, Cheryl M., Zhang, Xuexin, Kashiwagi, Kaori, Shirai, Yasuhito, Trebak, Mohamed, Loegering, Daniel J., Saito, Naoaki, Lennartz, Michelle R.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Leukocyte Biology 2013
Assuntos:
Receptors, Signal Transduction, & Genes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685018/
https://ncbi.nlm.nih.gov/pubmed/23670290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1212634
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