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Pivotal Role of Mouse Mast Cell Protease 4 in the Conversion and Pressor Properties of Big-Endothelin-1
The serine protease chymase has been reported to generate intracardiac angiotensin-II (Ang-II) from Ang-I as well as an intermediate precursor of endothelin-1 (ET-1), ET-1 (1–31) from Big-ET-1. Although humans possess only one chymase, several murine isoforms are documented, each with its own specif...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3684843/ https://ncbi.nlm.nih.gov/pubmed/23596057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.202275 |
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