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N-Methyl-D-Aspartic Acid Receptor Activation Downregulates Expression of δ Subunit-Containing GABA(A) Receptors in Cultured Hippocampal Neurons
Neurosteroids are endogenous allosteric modulators of GABA(A) receptors (GABARs), and they enhance GABAR-mediated inhibition. However, GABARs expressed on hippocampal dentate granule neurons of epileptic animals are modified such that their neurosteroid sensitivity is reduced and δ subunit expressio...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3684822/ https://ncbi.nlm.nih.gov/pubmed/23585058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.084715 |
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