Common dysfunctional variants in ABCG2 are a major cause of early-onset gout

Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, a high-capacity urate transporter which regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout...

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Autori principali: Matsuo, Hirotaka, Ichida, Kimiyoshi, Takada, Tappei, Nakayama, Akiyoshi, Nakashima, Hiroshi, Nakamura, Takahiro, Kawamura, Yusuke, Takada, Yuzo, Yamamoto, Ken, Inoue, Hiroki, Oikawa, Yuji, Naito, Mariko, Hishida, Asahi, Wakai, Kenji, Okada, Chisa, Shimizu, Seiko, Sakiyama, Masayuki, Chiba, Toshinori, Ogata, Hiraku, Niwa, Kazuki, Hosoyamada, Makoto, Mori, Atsuyoshi, Hamajima, Nobuyuki, Suzuki, Hiroshi, Kanai, Yoshikatsu, Sakurai, Yutaka, Hosoya, Tatsuo, Shimizu, Toru, Shinomiya, Nariyoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684804/
https://ncbi.nlm.nih.gov/pubmed/23774753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02014
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