A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians

BACKGROUND: In studies on the genetics of human aging, we observed an age-related variation of the 3'APOB-VNTR genotypic pool (alleles: Short, S, <35 repeats; Medium, M, 35–39 repeats; Long, L, >39 repeats) with the homozygous SS genotype showing a convex frequency trajectory in a healthy...

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Detalhes bibliográficos
Main Authors: Garasto, Sabrina, Berardelli, Maurizio, DeRango, Francesco, Mari, Vincenzo, Feraco, Emidio, De Benedictis, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC368435/
https://ncbi.nlm.nih.gov/pubmed/15028112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-5-3
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