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Alternative Chemical Modifications Reverse the Binding Orientation of a Pharmacophore Scaffold in the Active Site of Macrophage Migration Inhibitory Factor

Pharmacophores are chemical scaffolds upon which changes in chemical moieties (R-groups) at specific sites are made to identify a combination of R-groups that increases the therapeutic potency of a small molecule inhibitor while minimizing adverse effects. We developed a pharmacophore based on a car...

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Hlavní autoři: Crichlow, Gregg V., Cheng, Kai Fan, Dabideen, Darrin, Ochani, Mahendar, Aljabari, Bayan, Pavlov, Valentin A., Miller, Edmund J., Lolis, Elias, Al-Abed, Yousef
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684284/
https://ncbi.nlm.nih.gov/pubmed/17526494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M701825200
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