Stage-Specific Roles for Tet1 and Tet2 in DNA Demethylation in Primordial Germ Cells

Primordial germ cells (PGCs) undergo dramatic rearrangements to their methylome during embryo-genesis, including initial genome-wide DNA demethylation that establishes the germline epigenetic ground state. The role of the 5-methylcytosine (5mC) dioxygenases Tet1 and Tet2 in the initial genome-wide D...

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Main Authors: Vincent, John J., Huang, Yun, Chen, Pao-Yang, Feng, Suhua, Calvopiña, Joseph H., Nee, Kevin, Lee, Serena A., Le, Thuc, Yoon, Alexander J., Faull, Kym, Fan, Guoping, Rao, Anjana, Jacobsen, Steven E., Pellegrini, Matteo, Clark, Amander T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684274/
https://ncbi.nlm.nih.gov/pubmed/23415914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.01.016
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