Hsp90 facilitates accurate loading of precursor piRNAs into PIWI proteins

PIWI-interacting RNAs (piRNAs) defend the genome against transposon activity in animal gonads. The Hsp90 chaperone machinery has been implicated in the piRNA pathway, but its exact role remains obscure. Here, we examined the effect of 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), an Hsp90-speci...

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Autori principali: Izumi, Natsuko, Kawaoka, Shinpei, Yasuhara, Satoshi, Suzuki, Yutaka, Sugano, Sumio, Katsuma, Susumu, Tomari, Yukihide
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2013
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Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683924/
https://ncbi.nlm.nih.gov/pubmed/23681506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.037200.112
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