Hsp90 facilitates accurate loading of precursor piRNAs into PIWI proteins

PIWI-interacting RNAs (piRNAs) defend the genome against transposon activity in animal gonads. The Hsp90 chaperone machinery has been implicated in the piRNA pathway, but its exact role remains obscure. Here, we examined the effect of 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), an Hsp90-speci...

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Detalhes bibliográficos
Main Authors: Izumi, Natsuko, Kawaoka, Shinpei, Yasuhara, Satoshi, Suzuki, Yutaka, Sugano, Sumio, Katsuma, Susumu, Tomari, Yukihide
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683924/
https://ncbi.nlm.nih.gov/pubmed/23681506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.037200.112
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