Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state

After four decades of research aimed at understanding tRNA selection on the ribosome, the mechanism by which ribosomal ambiguity (ram) mutations promote miscoding remains unclear. Here, we present two X-ray crystal structures of the Thermus thermophilus 70S ribosome containing 16S rRNA ram mutations...

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Main Authors: Fagan, Crystal E., Dunkle, Jack A., Maehigashi, Tatsuya, Dang, Mai N., Devaraj, Aishwarya, Miles, Stacey J., Qin, Daoming, Fredrick, Kurt, Dunham, Christine M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683721/
https://ncbi.nlm.nih.gov/pubmed/23630274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301585110
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