Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. Here, we demonstrate that aberrant inflammasome-induced microbiota plays a critical role in CRC dev...

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Detalhes bibliográficos
Main Authors: Hu, Bo, Elinav, Eran, Huber, Samuel, Strowig, Till, Hao, Liming, Hafemann, Anja, Jin, Chengcheng, Wunderlich, Claudia, Wunderlich, Thomas, Eisenbarth, Stephanie C., Flavell, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683709/
https://ncbi.nlm.nih.gov/pubmed/23696660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307575110
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