NLRP6 inflammasome is a regulator of colonic microbial ecology and risk for colitis

Inflammasomes are multi-protein complexes that function as sensors of endogenous or exogenous damage-associated molecular patterns. Here we show that deficiency of NLRP6 in mouse colonic epithelial cells results in reduced IL-18 levels and altered fecal microbiota characterized by expanded represent...

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Main Authors: Elinav, Eran, Strowig, Till, Kau, Andrew L., Henao-Mejia, Jorge, Thaiss, Christoph A., Booth, Carmen J., Peaper, David R., Bertin, John, Eisenbarth, Stephanie C., Gordon, Jeffrey I., Flavell, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140910/
https://ncbi.nlm.nih.gov/pubmed/21565393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.04.022
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