CD40 Gene Silencing Reduces the Progression of Experimental Lupus Nephritis Modulating Local Milieu and Systemic Mechanisms

Lupus nephritis (LN) is an autoimmune disorder in which co-stimulatory signals have been involved. Here we tested a cholesterol-conjugated-anti-CD40-siRNA in dendritic cells (DC) in vitro and in a model of LPS to check its potency and tissue distribution. Then, we report the effects of Chol-siRNA in...

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Detalhes bibliográficos
Main Authors: Ripoll, Èlia, Merino, Ana, Goma, Montse, Aran, Josep M., Bolaños, Nuria, de Ramon, Laura, Herrero-Fresneda, Immaculada, Bestard, Oriol, Cruzado, Josep M., Grinyó, Josep M., Torras, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683035/
https://ncbi.nlm.nih.gov/pubmed/23799000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065068
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