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Is Dynamic Autocrine Insulin Signaling Possible? A Mathematical Model Predicts Picomolar Concentrations of Extracellular Monomeric Insulin within Human Pancreatic Islets
Insulin signaling is essential for [Image: see text]-cell survival and proliferation in vivo. Insulin also has potent mitogenic and anti-apoptotic actions on cultured [Image: see text]-cells, with maximum effect in the high picomolar range and diminishing effect at high nanomolar doses. In order to...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682990/ https://ncbi.nlm.nih.gov/pubmed/23798995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064860 |
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