Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity. Our laboratory demonstrated earlier that in the diet-induced obesity (DIO) state, the appetite-suppressing neuropeptide α-melanocyte-stimulat...

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Autores principales: Çakir, Isin, Cyr, Nicole E., Perello, Mario, Litvinov, Bogdan Patedakis, Romero, Amparo, Stuart, Ronald C., Nillni, Eduardo A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682568/
https://ncbi.nlm.nih.gov/pubmed/23640886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.475343
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