Insulin-like Growth Factor I (IGF-I)-induced Chronic Gliosis and Retinal Stress Lead to Neurodegeneration in a Mouse Model of Retinopathy

Insulin-like growth factor I (IGF-I) exerts multiple effects on different retinal cell types in both physiological and pathological conditions. Despite the growth factor's extensively described neuroprotective actions, transgenic mice with increased intraocular levels of IGF-I showed progressiv...

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Hlavní autoři: Villacampa, Pilar, Ribera, Albert, Motas, Sandra, Ramírez, Laura, García, Miquel, de la Villa, Pedro, Haurigot, Virginia, Bosch, Fatima
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682564/
https://ncbi.nlm.nih.gov/pubmed/23620587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.468819
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