T Cell Factor 4 Is a Pro-catabolic and Apoptotic Factor in Human Articular Chondrocytes by Potentiating Nuclear Factor κB Signaling

T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are downstream effectors of Wnt/β-catenin signaling, which has been implicated in the development and progression of osteoarthritis (OA). This study aimed to investigate the role of TCF/LEF transcription factors in human articula...

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Main Authors: Ma, Bin, Zhong, Leilei, van Blitterswijk, Clemens A., Post, Janine N., Karperien, Marcel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682554/
https://ncbi.nlm.nih.gov/pubmed/23603903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453985
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