Erythrocytosis and Pulmonary Hypertension in a Mouse Model of Human HIF2A Gain of Function Mutation

The central pathway for oxygen-dependent control of red cell mass is the prolyl hydroxylase domain protein (PHD):hypoxia inducible factor (HIF) pathway. PHD site specifically prolyl hydroxylates the transcription factor HIF-α, thereby targeting the latter for degradation. Under hypoxia, this modific...

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Detalhes bibliográficos
Main Authors: Tan, Qiulin, Kerestes, Heddy, Percy, Melanie J., Pietrofesa, Ralph, Chen, Li, Khurana, Tejvir S., Christofidou-Solomidou, Melpo, Lappin, Terence R. J., Lee, Frank S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682519/
https://ncbi.nlm.nih.gov/pubmed/23640890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444059
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