Epigenetic Switching by the Metabolism-sensing Factors in the Generation of Orexin Neurons from Mouse Embryonic Stem Cells

The orexin system plays a central role in the integration of sleep/wake and feeding behaviors in a broad spectrum of neural-metabolic physiology. Orexin-A and orexin-B are produced by the cleavage of prepro-orexin, which is encoded on the Hcrt gene. To date, methods for generating other peptide neur...

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Main Authors: Hayakawa, Koji, Hirosawa, Mitsuko, Tabei, Yasuyuki, Arai, Daisuke, Tanaka, Satoshi, Murakami, Noboru, Yagi, Shintaro, Shiota, Kunio
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682516/
https://ncbi.nlm.nih.gov/pubmed/23625921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455899
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