Novel O-GlcNAcylation on Ser(40) of canonical H2A isoforms specific to viviparity

We report here newly discovered O-linked-N-acetylglucosamine (O-GlcNAc) modification of histone H2A at Ser(40) (H2AS40Gc). The mouse genome contains 18 H2A isoforms, of which 13 have Ser(40) and the other five have Ala(40). The combination of production of monoclonal antibody and mass spectrometric...

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Publicado en:Sci Rep
Main Authors: Hirosawa, Mitsuko, Hayakawa, Koji, Yoneda, Chikako, Arai, Daisuke, Shiota, Hitoshi, Suzuki, Takehiro, Tanaka, Satoshi, Dohmae, Naoshi, Shiota, Kunio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018834/
https://ncbi.nlm.nih.gov/pubmed/27615797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31785
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