Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase(RT)-associated DNA polymerase and Ribonuclease H (RNase H) activities effective also on the RNase H activity of non-nucleoside resistant RTs

The HIV-1 reverse transcriptase (RT) has two associated activities, DNA polymerase and Ribonuclease H (RNase H), both essential for viral replication and validated drug targets. While all RT inhibitors approved for therapy target the DNA polymerase activity, the search of new RT inhibitors which tar...

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Bibliografiska uppgifter
Huvudupphovsmän: Esposito, Francesca, Kharlamova, Tatyana, Distinto, Simona, Zinzula, Luca, Cheng, Yung-Chi, Dutschman, Ginger, Floris, Giovanni, Markt, Patrick, Corona, Angela, Tramontano, Enzo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682423/
https://ncbi.nlm.nih.gov/pubmed/21348941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2011.08057.x
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