A gastrin precursor, gastrin-gly, upregulates VEGF expression in colonic epithelial cells through an HIF-1-independent mechanism

One of the major angiogenic factor released by tumor cells is VEGF. Its high expression is correlated with poor prognosis in colorectal tumors. In colon cancer, gastrin gene expression is also upregulated. In these tumors, gastrin precursors are mainly produced and act as growth factors. Recently, a...

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Main Authors: Bertrand, Claudine, Kowalski-Chauvel, Aline, Do, Catherine, Résa, Cécile, Najib, Souad, Daulhac, Laurence, Wang, Timothy C., Ferrand, Audrey, Seva, Catherine
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682422/
https://ncbi.nlm.nih.gov/pubmed/19876923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25001
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