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Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair

mRNAs can be targeted to specific neuronal subcellular domains, which enables rapid changes in the local proteome through local translation. This mRNA-based mechanism links extrinsic signals to spatially restricted cellular responses and can mediate stimulus-driven adaptive responses such as dendrit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jung, Hosung, Yoon, Byung C., Holt, Christine E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682205/
https://ncbi.nlm.nih.gov/pubmed/22498899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn3210
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