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A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant
To assess the consequences of inactivation of heat shock factor 1 (HSF1) during aging, we analyzed the effect of HSF1 K80Q, a mutant unable to bind DNA, and of dnHSF1, a mutant lacking the activation domain, on the transcriptome of cells 6 and 24 h after heat shock. The primary response to heat shoc...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer Netherlands
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682012/ https://ncbi.nlm.nih.gov/pubmed/23321918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-012-0400-0 |
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