Co-chaperones are limiting in a depleted chaperone network

To probe the limiting nodes in the chaperoning network which maintains cellular proteostasis, we expressed a dominant negative mutant of heat shock factor 1 (dnHSF1), the regulator of the cytoplasmic proteotoxic stress response. Microarray analysis of non-stressed dnHSF1 cells showed a two- or more...

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Main Authors: Heldens, Lonneke, Dirks, Ron P., Hensen, Sanne M. M., Onnekink, Carla, van Genesen, Siebe T., Rustenburg, François, Lubsen, Nicolette H.
Formato: Artigo
Idioma:Inglês
Publicado: SP Birkhäuser Verlag Basel 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981734/
https://ncbi.nlm.nih.gov/pubmed/20556630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0430-7
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