Effect of the Deletion of Genes Encoding Proteins of the Extracellular Virion Form of Vaccinia Virus on Vaccine Immunogenicity and Protective Effectiveness in the Mouse Model

Antibodies to both infectious forms of vaccinia virus, the mature virion (MV) and the enveloped virion (EV), as well as cell-mediated immune response appear to be important for protection against smallpox. EV virus particles, although more labile and less numerous than MV, are important for dissemin...

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Main Authors: Meseda, Clement A., Campbell, Joseph, Kumar, Arunima, Garcia, Alonzo D., Merchlinsky, Michael, Weir, Jerry P.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681963/
https://ncbi.nlm.nih.gov/pubmed/23785523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067984
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