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Sub-Inhibitory Concentrations of Human α-defensin Potentiate Neutralizing Antibodies against HIV-1 gp41 Pre-Hairpin Intermediates in the Presence of Serum

Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum. In this study, we have examined the effect of sub-inhibitory concentratio...

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Autors principals: Demirkhanyan, Lusine, Marin, Mariana, Lu, Wuyuan, Melikyan, Gregory B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681749/
https://ncbi.nlm.nih.gov/pubmed/23785290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003431
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