The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein

Spinal muscular atrophy is an inherited motor neuron disease that results from a deficiency of the survival of motor neuron (SMN) protein. SMN is ubiquitinated and degraded through the ubiquitin proteasome system (UPS). We have previously shown that proteasome inhibition increases SMN protein levels...

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Autori principali: Kwon, Deborah Y., Dimitriadi, Maria, Terzic, Barbara, Cable, Casey, Hart, Anne C., Chitnis, Ajay, Fischbeck, Kenneth H., Burnett, Barrington G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2013
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681692/
https://ncbi.nlm.nih.gov/pubmed/23615451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-01-0042
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