Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis

BACKGROUND: Osteosarcoma (OS) is the most common primary bone malignancy with a high propensity for local invasion and distant metastasis. Limited by the severe toxicity of conventional agents, the therapeutic bottleneck of osteosarcoma still remains unconquered. Flavokawain B (FKB), a kava extract,...

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Hauptverfasser: Ji, Tao, Lin, Carol, Krill, Lauren S, Eskander, Ramez, Guo, Yi, Zi, Xiaolin, Hoang, Bang H
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681603/
https://ncbi.nlm.nih.gov/pubmed/23764122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-55
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