Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer

INTRODUCTION: The estrogen receptor (ER) co-regulator proline glutamic acid and leucine-rich protein 1 (PELP1) is a proto-oncogene that modulates epigenetic changes on ER target gene promoters via interactions with lysine-specific histone demethylase 1 (KDM1). In this study, we assessed the therapeu...

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Hauptverfasser: Cortez, Valerie, Mann, Monica, Tekmal, Seshidhar, Suzuki, Takayoshi, Miyata, Naoki, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Sood, Anil K, Vadlamudi, Ratna K
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680946/
https://ncbi.nlm.nih.gov/pubmed/22812534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3229
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