Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met

INTRODUCTION: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown clinical efficacy in lung, colon, and pancreatic cancers. In lung cancer, resistance to EGFR TKIs correlates with amplification of the hepatocyte growth factor (HGF) receptor tyrosine kinase Met. Breas...

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Hlavní autoři: Mueller, Kelly L, Madden, Julie M, Zoratti, Gina L, Kuperwasser, Charlotte, List, Karin, Boerner, Julie L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680928/
https://ncbi.nlm.nih.gov/pubmed/22788954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3224
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