Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met

INTRODUCTION: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown clinical efficacy in lung, colon, and pancreatic cancers. In lung cancer, resistance to EGFR TKIs correlates with amplification of the hepatocyte growth factor (HGF) receptor tyrosine kinase Met. Breas...

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Main Authors: Mueller, Kelly L, Madden, Julie M, Zoratti, Gina L, Kuperwasser, Charlotte, List, Karin, Boerner, Julie L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680928/
https://ncbi.nlm.nih.gov/pubmed/22788954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3224
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