Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met

INTRODUCTION: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown clinical efficacy in lung, colon, and pancreatic cancers. In lung cancer, resistance to EGFR TKIs correlates with amplification of the hepatocyte growth factor (HGF) receptor tyrosine kinase Met. Breas...

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Autors principals: Mueller, Kelly L, Madden, Julie M, Zoratti, Gina L, Kuperwasser, Charlotte, List, Karin, Boerner, Julie L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680928/
https://ncbi.nlm.nih.gov/pubmed/22788954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3224
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