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Investigation of NADH Binding, Hydride Transfer, and NAD(+) Dissociation during NADH Oxidation by Mitochondrial Complex I Using Modified Nicotinamide Nucleotides

[Image: see text] NADH:ubiquinone oxidoreductase (complex I) is a complicated respiratory enzyme that conserves the energy from NADH oxidation, coupled to ubiquinone reduction, as a proton motive force across the mitochondrial inner membrane. During catalysis, NADH oxidation by a flavin mononucleoti...

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Detalhes bibliográficos
Main Authors: Birrell, James A., Hirst, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680915/
https://ncbi.nlm.nih.gov/pubmed/23683271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3016873
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