A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Their Differentiated Phenotype

Our previous studies demonstrated that Wnt/GSK-3/β-catenin and mTOR signaling are necessary to stimulate proliferative processes in adult human β-cells. Direct inhibition of GSK-3, that engages Wnt signaling downstream of the Wnt receptor, increases β-catenin nuclear translocation and β-cell prolife...

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Detalhes bibliográficos
Main Authors: Aly, Haytham, Rohatgi, Nidhi, Marshall, Connie A., Grossenheider, Tiffani C., Miyoshi, Hiroyuki, Stappenbeck, Thaddeus S., Matkovich, Scot J., McDaniel, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680388/
https://ncbi.nlm.nih.gov/pubmed/23776620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066131
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