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Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury

Acetaminophen (APAP), a widely-used analgesic agent, can cause liver injury through increased nitrative stress, leading to protein nitration. However, the identities of nitrated proteins and their roles in hepatotoxicity are poorly understood. Thus, we aimed at studying the mechanism of APAP-induced...

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Detalhes bibliográficos
Main Authors: Abdelmegeed, Mohamed A., Jang, Sehwan, Banerjee, Atrayee, Hardwick, James P., Song, Byoung-Joon
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680365/
https://ncbi.nlm.nih.gov/pubmed/23454065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.02.018
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