Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats

BACKGROUND: Stiff Person Syndrome (SPS) is a rare autoimmune movement disorder characterized by the presence of autoantibodies specific to the smaller isoform of glutamate decarboxylase (GAD65). A pathological role of these antibodies has been suggested by their capacity to inhibit GAD65 enzyme acti...

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Detalhes bibliográficos
Main Authors: Hampe, Christiane S, Petrosini, Laura, De Bartolo, Paola, Caporali, Paola, Cutuli, Debora, Laricchiuta, Daniela, Foti, Francesca, Radtke, Jared R, Vidova, Veronika, Honnorat, Jérôme, Manto, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680042/
https://ncbi.nlm.nih.gov/pubmed/23738610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-8-82
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