The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding

BACKGROUND: High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glycerol-3-phosphate acyltransferase (GPAT) activity and transcriptional regulation...

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Главные авторы: Henriksen, Bradley S, Curtis, Mary E, Fillmore, Natasha, Cardon, Brandon R, Thomson, David M, Hancock, Chad R
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679947/
https://ncbi.nlm.nih.gov/pubmed/23725555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1758-5996-5-29
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