The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding

BACKGROUND: High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glycerol-3-phosphate acyltransferase (GPAT) activity and transcriptional regulation...

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Autores principales: Henriksen, Bradley S, Curtis, Mary E, Fillmore, Natasha, Cardon, Brandon R, Thomson, David M, Hancock, Chad R
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679947/
https://ncbi.nlm.nih.gov/pubmed/23725555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1758-5996-5-29
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