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Apoptotic tumor cells induce IL-27 release from human DC to activate regulatory T cells that express CD69 and attenuate cytotoxicity
Intrinsic immunosuppression is a major obstacle for a successful cancer therapy. Mechanisms how immunosuppression is induced and regulated in humans are ill-defined. A micro-environmental component that might prevent anti-tumor immunity is the presence of dying tumor cells, which is abundant followi...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679920/ https://ncbi.nlm.nih.gov/pubmed/22678911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142093 |
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