Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset

Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites (phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose-phosphate pathways accumulated by infected or metabolically distressed cells. The underlying mechanisms are unknown. We show that treatment...

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Detalhes bibliográficos
Main Authors: Harly, Christelle, Guillaume, Yves, Nedellec, Steven, Peigné, Cassie-Marie, Mönkkönen, Hannu, Mönkkönen, Jukka, Li, Jianqiang, Kuball, Jürgen, Adams, Erin J., Netzer, Sonia, Déchanet-Merville, Julie, Léger, Alexandra, Herrmann, Thomas, Breathnach, Richard, Olive, Daniel, Bonneville, Marc, Scotet, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679641/
https://ncbi.nlm.nih.gov/pubmed/22767497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-430470
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