Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors

Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear envelope. About 30 different proteins (nucleoporins, nups) arrange around a central eightfold rotational axis to build the modular NPC. Nup188 and Nup192 are related and evolutionary conserved, large nuc...

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Detalles Bibliográficos
Main Authors: Andersen, Kasper R, Onischenko, Evgeny, Tang, Jeffrey H, Kumar, Pravin, Chen, James Z, Ulrich, Alexander, Liphardt, Jan T, Weis, Karsten, Schwartz, Thomas U
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2013
Assuntos:
Biophysics and Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679522/
https://ncbi.nlm.nih.gov/pubmed/23795296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00745
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