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Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity
DNA damage activates nuclear Abl tyrosine kinase to stimulate intrinsic apoptosis in cancer cell lines and mouse embryonic stem cells. To examine the in vivo function of nuclear Abl in apoptosis, we generated Abl-μNLS (μ, mutated in nuclear localization signals) mice. We show here that cisplatin-ind...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679464/ https://ncbi.nlm.nih.gov/pubmed/23660976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.42 |
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