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Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity

DNA damage activates nuclear Abl tyrosine kinase to stimulate intrinsic apoptosis in cancer cell lines and mouse embryonic stem cells. To examine the in vivo function of nuclear Abl in apoptosis, we generated Abl-μNLS (μ, mutated in nuclear localization signals) mice. We show here that cisplatin-ind...

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Autori principali: Sridevi, P, Nhiayi, M K, Wang, J Y J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679464/
https://ncbi.nlm.nih.gov/pubmed/23660976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.42
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