Topoisomerase-specific drug sensitivity in relation to cell cycle progression.

The nuclear enzyme DNA topoisomerase II catalyzes the breakage and resealing of duplex DNA and plays an important role in several genetic processes. It also mediates the DNA cleavage activity and cytotoxicity of clinically important anticancer agents such as etoposide. We have examined the activity...

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Detalles Bibliográficos
Autores principales: Chow, K C, Ross, W E
Formato: Artigo
Lenguaje:Inglês
Publicado: 1987
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC367945/
https://ncbi.nlm.nih.gov/pubmed/2823120
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