Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors

BACKGROUND: Hippocampal demyelination, a common feature of postmortem multiple sclerosis (MS) brains, reduces neuronal gene expression and is a likely contributor to the memory impairment that is found in greater than 40% of individuals with (MS). How demyelination alters neuronal gene expression is...

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Main Authors: Dutta, Ranjan, Chomyk, Anthony M., Chang, Ansi, Ribaudo, Michael V., Deckard, Sadie A., Doud, Mary K., Edberg, Dale D., Bai, Brian, Li, Michael, Baranzini, Sergio E., Fox, Robert J., Staugaitis, Susan M., Macklin, Wendy B., Trapp, Bruce D
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679350/
https://ncbi.nlm.nih.gov/pubmed/23595422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23860
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