Fbw7 Repression by Hes5 Creates a Feedback Loop That Modulates Notch-Mediated Intestinal and Neural Stem Cell Fate Decisions

FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct set of substrates. Most FBW7 targets have important...

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Détails bibliographiques
Auteurs principaux: Sancho, Rocio, Blake, Sophia M., Tendeng, Christian, Clurman, Bruce E., Lewis, Julian, Behrens, Axel
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679002/
https://ncbi.nlm.nih.gov/pubmed/23776410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001586
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