Fbw7 Repression by Hes5 Creates a Feedback Loop That Modulates Notch-Mediated Intestinal and Neural Stem Cell Fate Decisions

FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct set of substrates. Most FBW7 targets have important...

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Detaylı Bibliyografya
Asıl Yazarlar: Sancho, Rocio, Blake, Sophia M., Tendeng, Christian, Clurman, Bruce E., Lewis, Julian, Behrens, Axel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679002/
https://ncbi.nlm.nih.gov/pubmed/23776410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001586
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