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Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits

To develop a functional nervous system, axons must initially navigate through a complex environment, directed by guidance ligands and receptors. These receptors must link to intracellular signaling cascades to direct axon pathfinding decisions. The Abelson tyrosine kinase (Abl) plays a crucial role...

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Autors principals: O’Donnell, Michael P., Bashaw, Greg J.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3678342/
https://ncbi.nlm.nih.gov/pubmed/23720041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.093831
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